C UTANEOUS LYMPHOID infiltrates represent one of the most vexing problems in dermatology and dermatopathology. Many colleagues experience frustration when facing the difficulties in diagnosis, classification, and management of such patients. In this issue of Seminars in Cutaneous Medicine and Surgery we asked well-known experts to summarize recent advances and concepts in this field, keeping in mind the practical problems of routine work in a dermatologic practice. In this context one should stress again that diagnosis and classification of cutaneous lymphomas and pseudolymphomas can be achieved only on careful analysis of clinical, histopathologic, immunohistologic, and molecular features of the cutaneous infiltrates.
In this issue of Seminars in Cutaneous Medicine and Surgery we asked well-known experts to summarize recent advances and concepts in this field, keeping in mind the practical problems of routine work in a dermatologic practice.
CUTANEOUS MALIGNANT lymphomas represent a heterogeneous group of T- and B-cell neoplasms, which can involve the skin primarily or secondarily.
Cutaneous lymphomas are a heterogeneous group of lymphoproliferative disorders derived from T cells, B cells and, in rare cases, natural killer cells.
The diagnosis and classification of cutaneous lymphomas is a challenge for the dermatopathologist. This is particularly true for determining the distinction between a malignant lymphoma and a benign reactive infiltrate (pseudolymphoma).
We will review the salient features of patch, plaque, and tumor stage mycosis fungoldes in this article and follow with a discussion of these variant clinicopathologic presentations and of therapeutic modalities.