PHOTODERMATOLOGY: CURRENT PRINCIPLES AND PRACTICE
Dec
2011
Vol. 30. No. 4
Introduction
Knowledge of light-skin interactions remains a critical
aspect of dermatology. During the past decade, advances
have been made with the use of light-based technologies
in the diagnosis and management of skin disease.
Changes in demographics within the United States and
other western countries have highlighted the need for a
better understanding of photobiology in skin of color. The
increase in skin cancer incidence, including melanoma,
continues to challenge us to come up with more optimal
photoprotective measures. This issue of Seminars in Cutaneous
Medicine and Surgery is devoted to current principles
and practice in photodermatology.
The goal is to provide a snapshot of up-to-date information
on disorders, therapies, and pathophysiologic mechanisms
influenced by ultraviolet and visible light. Basic
science data are incorporated with practical clinical approaches,
resulting in a meaningful and relevant discussion
of key topics in photodermatology.
Ultraviolet Radiation and Melanoma
Melanoma is a particularly aggressive type of skin cancer, and its incidence has been increasing
steadily since the 1970s. This article will review the extensive epidemiologic data demonstrating
that ultraviolet radiation (UVR) exposure, from the sun or artificial tanning beds, is the
most important environmental risk factor for melanoma; the multiple detrimental effects of UVR
on human skin, including DNA damage through the formation of dimeric photoproducts, gene
mutations, oxidative stress, inflammation, and immunosuppression, all of which contribute to
melanomagenesis; and the evidence that protection from UVR exposure, whether by melanin
or by sunscreen, reduces the risk of developing melanoma.
Semin Cutan Med Surg 30:222-228 © 2011 Elsevier Inc. All rights reserved.
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Update on Photodermatoses
Interactions with ultraviolet radiation (UVR) and chromophores in the skin happen on a
daily basis. Photodermatoses, which are abnormal responses to UV exposure, can be
classified into subgroups based on pathogenesis. This review will discuss the clinical
features, pathogenesis, photobiologic evaluation, prognosis and therapies of the most
common photodermatoses.
Semin Cutan Med Surg 30:229-238 © 2011 Elsevier Inc. All rights reserved.
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