In a busy dermatology practice, we frequently encounter patients whose psychological problems appear just as important as their dermatological ones. Some examples include patients with delusion of parasitosis (Morgellons syndrome), neurotic excoriations, trichotillomania, cutaneous sensory disorder and any patient whose skin condition is worsened with emotional stress. Studies have shown that as many as one-third of dermatology patients have a significant psychological issue in connection with their skin complaint. Therefore, it is helpful in clinical practice to know as much as possible about the management of psychological issues in dermatology. On the other hand, despite its high relevance to our practice, psychodermatology is rarely covered in dermatology residency programs. In this issue of Seminars in Cutaneous Medicine and Surgery, we provide a rare opportunity to learn about psychodermatology. You will find the papers presented herein to be concise and clinically useful. This issue covers many important topics such as the optimal approach to the psychodermatology patient, the role of emotional stress in worsening skin conditions, and the impact of disfiguring skin disorders on quality of life. We also review the diagnosis and management of well-known psychodermatological disorders, such as delusional disorders, cutaneous sensory disorders, body dysmorphic disorders, obsessive-compulsive disorders in dermatology, trichotillomania, onychophagia, and neurotic excoriations. Lastly, both pharmacologic and nonpharmacologic approaches to the management of psychodermatology patients are discussed. We hope that you find this issue easy to comprehend and practical. Now that you have a compendium of psychodermatology in your hands, you are about to embark on an exciting journey. As you flip through the pages of this issue, you will uncover some fascinating topics in psychodermatology written by well-known experts in dermatology and psychiatry from around the world.