Thomas E. Rohrer

Guest Editor for the following articles:

Dec
2010
Vol. 29. No. 4

Pathways to Melanoma

Hensin Tsao, MD | Justin M. Ko, MD, MBA | Nicole F. Velez, MD

Melanoma is one of the most aggressive and yet poorly understood of human malignancies. Advances in genomics has allowed a more nuanced understanding of the disease, moving beyond the traditional dysplastic nevus-to-melanoma model and identifying multiple divergent oncogenic pathways leading to melanoma. An understanding of the molecular mechanisms driving melanoma has opened the doors for the development of targeted therapeutic approaches. As we enter the era of personalized medicine, it will be critical for clinicians to both appreciate and be able to determine the molecular profile of their patients’ melanoma because this profile will guide risk stratification, genetic counseling, and treatment customization. A review of the divergent pathways of melanoma development is presented here, with a particular emphasis on recently identified mutations, and their implications for patient care.
Semin Cutan Med Surg 29:210-217 © 2010 Published by Elsevier Inc.

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Mar
2011
Vol. 30. No. 1

Do Lasers or Topicals Really Work for Nonmelanoma Skin Cancers?

Lori A. Brightman, MD | Melanie Warycha, MD | Robert Anolik, MD | Roy G Geronemus, MD

Novel strategies are urgently needed to address the millions of nonmelanoma skin cancers
treated in the United States annually. The need is greatest for those patients who are poor
surgical candidates or those prone to numerous nonmelanoma skin cancers and therefore
at risk for marked disfigurement. Traditional treatment strategies include electrosurgery
with curettage, radiation therapy, cryotherapy, excision, and Mohs micrographic surgery.
Alternatives to traditional treatment, including topical medications and light or laser therapies,
are becoming popular; however, there are various degrees of efficacy among these
alternative tactics. These alternatives include topical retinoids, peels, 5-fluorouracil, imiquimod,
photodynamic therapy, and lasers. The purpose of this paper is to review the
available data regarding these alternative strategies and permit the reader to have a sense
of which therapies are reasonable options for care.
Semin Cutan Med Surg 30:14-25 © 2011 Elsevier Inc. All rights reserved.

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Dec
2003
Vol. 22. No. 4

Planning the Closure

Thomas Roher, MD

While excisional surgery is as much an art form as it is a science or technique, there are many principles to keep in mind when planning the surgical excision and closure.

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Dec
2010
Vol. 29. No. 4

Dermoscopy of Benign and Malignant Neoplasms in the Pediatric Population

A.A. Marghoob, MD | Christoph Lanschuetzer, MD | Helen C. Haliasos, MD | Helmut Hinter, MD | Iris Zalaudek, MD | Josep Malvehy, MD | Rainer Hofmann-Wellenhof, MD | Ralph P. Braun, MD

Dermoscopy is a noninvasive technique that enables visualization of subsurface colors and structures within the skin that are imperceptible to the naked eye. The dermatoscope allows
the physician to examine both the macroscopic and microscopic primary morphology of skin lesions, identify subtle clinical clues, confirm naked-eye clinical diagnoses, and monitor treatment progress while posing little threat to the young patient. Dermoscopic findings have been formulated into diagnostic criteria that assist experienced clinicians in differentiating benign and malignant neoplasms. In this review, clinical morphology of melanocytic nevi and melanoma in the pediatric population is examined and the relevant dermoscopic findings and histopathologic correlates that aid in the diagnosis and management of these lesions are described.
Semin Cutan Med Surg 29:218-231 © 2010 Published by Elsevier Inc.

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Dec
2003
Vol. 22. No. 4

Practical Perioral Closures

J. Ramsey Mellette, Jr, MD | James T. Chapman, MD

THE LIP is one of the most complex cosmetic units of the face.

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