H. Peter Soyer

Guest Editor for the following articles:

Vol. 28. No. 3

Dermoscopy—The Ultimate Tool for Melanoma Diagnosis

Antonia Martino, MD | Gerardo Ferrara, MD | Giuseppe Argenziano, MD | Iris Zalaudek, MD | Karin Di Nola, MD | Sabrina Francione, MD

“We are beginning to move away from clinicopathologic diagnosis into an era of clinicoimaging
diagnosis.” This vision became a fact, as the dermatoscope represents nowadays
the dermatologist stethoscope. This is not only because dermoscopy reveals a new and
fascinating morphologic dimension of pigmented and nonpigmented skin tumors, but also
because it improves the recognition of a growing number of skin symptoms in general
dermatology. Melanoma detection remains the most important indication of dermoscopy
and in melanoma screening the aim of dermoscopy is to maximize early detection while
minimizing the unnecessary excision of benign skin tumors. In the last few years, 3
meta-analyses and 2 randomized studies have definitely proven that dermoscopy allows
improving sensitivity for melanoma as compared to the naked eye examination alone. This
is the consequence of at least 3 issues: first, the presence of early dermoscopy signs that
are visible in melanoma much before the appearance of the classical clinical features;
second, an increased attitude of clinicians to check more closely clinically banal-looking
lesions; third, an improved attitude of clinicians to monitor their patients.
Semin Cutan Med Surg 28:142-148 © 2009 Elsevier Inc. All rights reserved.

Vol. 28. No. 3

The Morphologic Universe of Melanocytic Nevi

Gerardo Ferrara, MD | Giovanni Docimo, MD | Giuseppe Argenziano, MD | Imma Savarese, MD | Iris Zalaudek, MD | Manuela Manzo, MD

Different types of nevi do exist in relation to their epidemiology, morphology, evolution, and
associated melanoma risk. The introduction of dermoscopy opened a new dimension of the
morphologic universe of nevi and allowed clinicians to observe colors and structures within
nevi that are otherwise not visible to the unaided eye. Because most of these colors and
structures correspond to well-defined histopathologic correlates, dermoscopy enables
clinicians to date to more precisely predict the histopathology diagnosis and thereby
improve on their clinical diagnostic accuracy. Besides the diagnostic impact, the in vivo
observation of thousands of nevi using dermoscopy and digital dermoscopic follow-up has
opened new understanding about the evolution of nevi and factors influencing the nevus
pattern. In consequence, a new nevus classification has been proposed, subdividing nevi
into 7 categories, which are as follows: (1) globular/cobblestone nevi, (2) reticular nevi, (3)
starburst nevi, (4) homogeneous blue nevi, (5) nevi on special body sites, (6) nevi with
special features, and (7) and unclassifiable melanocytic proliferations. This article provides
an overview on the morphologic classification of nevi and the factors influencing the nevus
Semin Cutan Med Surg 28:149-156 © 2009 Elsevier Inc. All rights reserved.

Vol. 28. No. 3

Dermoscopic-Pathologic Correlation: Apropos of Six Equivocal Cases

Caterina M. Giorgio, MD | Gerardo Ferrara, MD | Giuseppe Argenziano, MD | Harald Kittler, MD | Iris Zalaudek, MD

The increasing use of dermoscopy in preoperative diagnosis of melanocytic skin
neoplasms is impacting on routine histopathology to a relevant extent. We herein
present the dermoscopic-pathologic features of 6 cases of histopathologically controversial
melanocytic skin neoplasms. By illustrating these cases, we emphasize at least
3 different fields of interest for a combined (clinico-)dermoscopic-pathologic diagnostic
approach, namely, information about the evolution of lesions; detection of gross
sampling errors; definition of peculiar clinicopathologic entities. The theoretic and
practical aspects of a close interaction among dermoscopists and histopathologists are
itemized in detail.
Semin Cutan Med Surg 28:157-164 © 2009 Elsevier Inc. All rights reserved.

Vol. 28. No. 3

Dermoscopy Research—An Update

A.A. Marghoob, MD | Harold S. Rabinovitz, MD | Ralph P. Braun, MD

Dermoscopy increases the clinician’s diagnostic accuracy by as much as 30% over that of
unaided visual clinical inspection alone and has been confirmed in 3 separate evidencebased
publications using a meta-analysis of the literature. It can be viewed as an in vivo
bridge between clinical morphology and histopathology. This “bridge” has provided clinician
researchers with many new insights into morphology and tumor biology. In this article,
we provide the reader with an overview of the different aspects of dermoscopy as a
research tool. We cover different aspects, such as the new equipment, new structures, the
importance of blood vessels, etc.
Semin Cutan Med Surg 28:165-171 © 2009 Published by Elsevier Inc

Vol. 28. No. 3

Reflectance Confocal Microscopy—State-of-Art and Research Overview

Armin Gerger, MD | Elisabeth M.T. Wurm, MD | Erika Richtig, MD | Josef Smolle, MD | Rainer Hofmann-Wellenhof, MD | Silvia Koller, MD | Verena Ahlgrimm-Siess, MD

Reflectance confocal microscopy (RCM) enables in vivo imaging of human skin at a quasi
histologic resolution. The black-and-white RCM images show horizontal sections of the
skin, at a maximum depth of 350 m. To date, the RCM features of a significant number of
skin conditions have been described. The main focus of the research community investigating
RCM, however, lies on describing and diagnosing melanocytic skin lesions. Taking
into account all RCM studies dealing with diagnostic accuracy in melanocytic skin lesions,
sensitivity and specificity of approximately 90% and 86% could be found. Improvement of
diagnostic accuracy, improved assessment of dermoscopic-histologic correlation, in vivo
biopsy side selection, surgical margin assessment, and response control of conservative
therapies in skin diseases are some of the major advantages of this novel imaging method.
Additionally, RCM holds inherent potential for teledermatologic application and automated
image analyzing. This article describes morphologic features of diverse skin lesions and
features of “normal skin,” summarizes diagnostic advances of RCM, compares studies
dealing with diagnostic applicability, and discusses further research goals of this exciting
new imaging technique.
Semin Cutan Med Surg 28:172-179 © 2009 Elsevier Inc. All rights reserved.