Emmy M. Graber

Guest Editor for the following articles:

Vol. 28. No. 4

Radiofrequency Devices for Body Shaping: A Review and Study of 12 Patients

Anne M. Chapas, MD | Lori A. Brightman, MD | Robert Anolik, MD | Roy G Geronemus, MD

Radiofrequency (RF) devices such as ThermaCool TC (Solta Medical Inc., Hayward, CA)
offer a nonablative and noninvasive treatment option for unwanted skin concerns of the
head, neck, and body. Relatively fewer studies address RF treatment on the body when
compared with the head and neck. The purpose of this report is to investigate the use of the
ThermaCool TC system with the novel Thermage Multiplex Tip for the enhancement of body
shape. Additionally, this report will review the literature of RF technology with a concentration
on body shaping. Twelve subjects underwent ThermaCool TC treatments using the
Thermage Multiplex Tip. Waist circumference, standardized photographs, skin laxity score,
global aesthetic improvement score, and patient satisfaction surveys were assessed at
baseline and several follow-up visits after treatment. Average waist circumference and skin
laxity scores decreased after ThermaCool TC treatment, using the Thermage Multiplex Tip
at follow-up visits held at 1, 2, 4, and 6 months after treatment. Global aesthetic improvement
score and patient satisfaction surveys reflected these objective clinical improvements.
RF devices, such as the ThermaCool TC offer a nonablative and noninvasive
treatment option for unwanted skin findings of the head, neck, and body.
Semin Cutan Med Surg 28:236-243 © 2009 Elsevier Inc. All rights reserved.

Vol. 35. No. 2

The use of hormonal agents in the treatment of acne

Dev S Chahal, BA | Larissa N Larsen, MD | Lauren A Hassoun, BS | Raja K Sivamani, MD, MS, CAT

Hormones and androgens play an important role in the pathogenesis of acne. Multiple hormonal modulators are now available for the treatment of acne. The efficacies and side effects of currently available hormonal agents are reviewed here including the use of oral contraceptives, spironolactone, flutamide, cyproterone acetate, finasteride, and cortexolone 17α-propionate. Hormonal therapies are an efficacious treatment option for acne among females. With the growing need to reduce antibiotic exposures, hormonal therapies should be more widely studied and incorporated into acne treatment strategies.

Semin Cutan Med Surg 35:68-73 © 2016 Frontline Medical Communications

Vol. 28. No. 4

Cryolipolysis for Reduction of Excess Adipose Tissue

Andrew A. Nelson, MD | Daniel Wasserman, MD | Mathew M. Avram, MD, JD

Controlled cold exposure has long been reported to be a cause of panniculitis in cases such
as popsicle panniculitis. Cryolipolysis is a new technology that uses cold exposure, or
energy extraction, to result in localized panniculitis and modulation of fat. Presently, the
Zeltiq cryolipolysis device is FDA cleared for skin cooling, as well as various other
indications, but not for lipolysis. There is, however, a pending premarket notification for
noninvasive fat layer reduction. Initial animal and human studies have demonstrated
significant reductions in the superficial fat layer thickness, ranging from 20% to 80%,
following a single cryolipolysis treatment. The decrease in fat thickness occurs gradually
over the first 3 months following treatment, and is most pronounced in patients with limited,
discrete fat bulges. Erythema of the skin, bruising, and temporary numbness at the
treatment site are commonly observed following treatment with the device, though these
effects largely resolve in approximately 1 week. To date, there have been no reports of
scarring, ulceration, or alterations in blood lipid or liver function profiles. Cryolipolysis is a
new, noninvasive treatment option that may be of benefit in the treatment of excess adipose
Semin Cutan Med Surg 28:244-249 © 2009 Elsevier Inc. All rights reserved.

Vol. 35. No. 2

Topical and oral therapeutic approach to rosacea

Lisa M Maier, MD | Yolanda R Helfrich, MD

Rosacea is an inflammatory condition of the skin, primarily affecting the central convexities of the face. Various topical and oral therapeutic approaches exist. Most have been developed to treat the papulopustular subtype of rosacea; however, other approaches can be used to treat the erythematotelangiectatic, ocular, and phymatous subtypes. This review provides a summary of available topical and oral approaches for the treatment of rosacea.

Semin Cutan Med Surg 35:74-78 © 2016 Frontline Medical Communications

Vol. 35. No. 2

Isotretinoin for acne and rosacea

Kendra D Watson, MD | Megha M Tollefson, MD | Rachel Y Miest, MD

Isotretinoin is a revolutionary medicine for the treatment of acne vulgaris, with new studies showing evidence of excellent clinical outcomes in treating rosacea. After 30 years of clinical experience, new insights are being gained into dosing strategies, recurrence prevention, and dose-related side effects. Previous controversial associations with inflammatory bowel diseases and mood disorders have hampered the use of this medication in some clinical situations, with new evidence disproving these claims. The teratogenicity of this medication mandates iPLEDGE compliance with government regulations. Clinicians should be knowledgeable about this medication including its side effects, teratogenicity, and its controversies in order to adequately counsel patients, dissuade fears, and obtain the best clinical outcome when treating acne and rosacea.

Semin Cutan Med Surg 35:79-86 © 2016 Frontline Medical Communications