Benign pigmented lesions and tattoos are often very responsive to laser treatment. The chromophore in most cases is melanin, although other endogenous and exogenous pigments can be targeted. The chromophore and its distribution in the skin, as well as the underlying biological processes, all help determine the best laser, if any, tor a given pigmented lesion. Epidermal lesions respond well to shorter wavelengths (up to 755 nm), whereas for deeper lesions, 694 nm or longer are typically used. The l,064-nm Nd:YAG laser is best for treating darker skinned individuals. Multicolored tattoos may need several wavelengths to best target individual ink colors.

SINCE THE EARLY 1960s, with the discovery of laser technology, melanocytic lesions and tattoos have been desired targets for laser therapy.