Liposonix is considered to be a nonsurgical treatment for body contouring that uses
high-intensity focused ultrasound (HIFU) to disrupt adipocytes percutaneously. We wanted
to find out about its efficacy, effectiveness, and so forth. The technique delivers energy
across the skin surface at a relatively low intensity, but brings this energy to a sharp focus
in the subcutaneous fat. At the skin surface, the intensity of the ultrasound energy is low
enough so that no damage occurs. The focusing of the ultrasound beam at specific depths
beneath the epidermis, combined with proprietary application techniques, results in adipose
tissue disruption. Once adipocytes have been disrupted, chemotactic signals activate
the body’s inflammatory response mechanisms. Macrophage cells are attracted to the area
to engulf and transport the lipids and cell debris. This results in an overall reduction in local
adipose tissue volume. Our clinical and histologic studies will show exactly what happens
under the skin. We did a series of studies on gross pathology and histology, and we tried
to correlate these with the clinical results. The histologies show clearly that adipocytes are
disrupted by HIFU. The pathologies show the lesions, but they are always at a safe distance
from dermis or the epidermis. The correlation between focal depth, energy levels, and
clinical results is evident. The average circumference reduction after treatment of the
abdomen and waist is 4-5 cm. Liposonix turns out to be a safe and effective technique for
nonsurgical body sculpting by reduction of fat deposits.
Semin Cutan Med Surg 28:257-262 © 2009 Elsevier Inc. All rights reserved.

Liposonix is considered to be a nonsurgical treatment for body contouring that uses
high-intensity focused ultrasound (HIFU) to disrupt adipocytes percutaneously. We wanted
to find out about its efficacy, effectiveness, and so forth. The technique delivers energy
across the skin surface at a relatively low intensity, but brings this energy to a sharp focus
in the subcutaneous fat. At the skin surface, the intensity of the ultrasound energy is low
enough so that no damage occurs. The focusing of the ultrasound beam at specific depths
beneath the epidermis, combined with proprietary application techniques, results in adipose
tissue disruption. Once adipocytes have been disrupted, chemotactic signals activate
the body’s inflammatory response mechanisms. Macrophage cells are attracted to the area
to engulf and transport the lipids and cell debris. This results in an overall reduction in local
adipose tissue volume. Our clinical and histologic studies will show exactly what happens
under the skin. We did a series of studies on gross pathology and histology, and we tried
to correlate these with the clinical results. The histologies show clearly that adipocytes are
disrupted by HIFU. The pathologies show the lesions, but they are always at a safe distance
from dermis or the epidermis. The correlation between focal depth, energy levels, and
clinical results is evident. The average circumference reduction after treatment of the
abdomen and waist is 4-5 cm. Liposonix turns out to be a safe and effective technique for
nonsurgical body sculpting by reduction of fat deposits.
Semin Cutan Med Surg 28:257-262 © 2009 Elsevier Inc. All rights reserved.