Atopic dermatitis (AD) is a chronic inflammatory skin disease with a complex pathogenesis.
It is clinically well-defined and represents one manifestation of the atopic state, along with
asthma, food allergy and/or allergic rhinitis. Within the last several decades, there has been
much evidence to support the contribution of immune mechanisms in the pathogenesis of
AD. It has also been documented that the prevalence of all atopic disease, including AD,
has been increasing, although the environmental factors that may be contributing to this
increase are not clearly defined. A better understanding of the underlying immunopathogenesis
of AD should aid in better clinical management and development of new treatment
options.
Semin Cutan Med Surg 27:138-143 © 2008 Elsevier Inc. All rights reserved

Atopic dermatitis (AD) is a chronic inflammatory skin disease with a complex pathogenesis.
It is clinically well-defined and represents one manifestation of the atopic state, along with
asthma, food allergy and/or allergic rhinitis. Within the last several decades, there has been
much evidence to support the contribution of immune mechanisms in the pathogenesis of
AD. It has also been documented that the prevalence of all atopic disease, including AD,
has been increasing, although the environmental factors that may be contributing to this
increase are not clearly defined. A better understanding of the underlying immunopathogenesis
of AD should aid in better clinical management and development of new treatment
options.
Semin Cutan Med Surg 27:138-143 © 2008 Elsevier Inc. All rights reserved