Dermatologists have long used cold-based therapeutic approaches for a variety of applications.  Based on the differences in chemical composition, it is possible to selectively target certain tissues rich with lipid, while sparing the surrounding tissue predominantly containing water. With historical observations of cold-induced panniculitis suggesting the feasibility of this strategy, cryolipolysis has emerged as a new methodology using controlled
cooling to selectively target fat. Both preclinical and clinical studies have established the safety and efficacy of cryolipolysis for noninvasive body contouring. This review will focus on the evolution of cryolipolysis from initial case reports of cold-induced panniculitis, to preclinical and clinical studies, and the current clinical practice.
Semin Cutan Med Surg 32:31-34 © 2013 Frontline Medical Communications

Dermatologists have long used cold-based therapeutic approaches for a variety of applications.
Based on the differences in chemical composition, it is possible to selectively
target certain tissues rich with lipid, while sparing the surrounding tissue predominantly
containing water. With historical observations of cold-induced panniculitis suggesting the
feasibility of this strategy, cryolipolysis has emerged as a new methodology using controlled
cooling to selectively target fat. Both preclinical and clinical studies have established
the safety and efficacy of cryolipolysis for noninvasive body contouring. This review
will focus on the evolution of cryolipolysis from initial case reports of cold-induced panniculitis,
to preclinical and clinical studies, and the current clinical practice.
Semin Cutan Med Surg 32:31-34 © 2013 Frontline Medical Communications