Glucocorticoid-induced osteoporosis (GIOP) is a serious complication resulting from longterm steroid treatment. In addition to several nonpharmacologic therapies recommended by the American College of Rheumatology, various pharmacologic therapies, such as calcium, vitamin D, hormone-replacement therapy, calcitonin, and bisphosphonates, can be used to prevent and/or treat GIOP. Bisphosphonates, which are potent inhibitors of bone resorption, are considered the most effective and first-line agents for increasing bone mineral density and decreasing the risk of fracture. Human parathyroid hormone has emerged as a promising agent for the treatment of severe GIOP when used alone or in
combination with a bisphosphonate.

Semin Cutan Med Surg 26:203-209 © 2007 Elsevier Inc. All rights reserved.