Systemic Therapy of Atopic Dermatitis: Welcome to the Revolution

Emerging Science and Management of Atopic Dermatitis

Systemic Therapy of Atopic Dermatitis: Welcome to the Revolution

Dec
2017
Vol. 36. No. 4
Lawrence F. Eichenfield, MD | Linda Stein Gold, MD

Until recently, systemic therapy of atopic dermatitis was limited to off-label use of immunomodulators, which can pose significant safety concerns, and treatment with systemic corticosteroids, not recommended in the most recent guidelines. The introduction of dupilumab in 2017 marked a major advance in systemic therapy for atopic dermatitis. It has demonstrated long-term efficacy in adults with moderate to severe disease, and is being studied in children. Several other biologic agents and “small molecules” with varying mechanisms of action are in phase 2 or 3 development.

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