Pathogenesis of Cutaneous Lymphomas

CUTANEOUS LYMPHOMAS

Pathogenesis of Cutaneous Lymphomas

Jun
2000
Vol. 19. No. 2
Reinhard Dummer | Jorg Willers | Jivko Kamarashev | Mirjana Urosevic | Gunter Burg

Cutaneous lymphomas are a heterogeneous group of lymphoproliferative disorders derived from T cells, B cells and, in rare cases, natural killer cells. The precise mechanisms of the lymphomagenesis are still obscure. However, there are various factor’s involved. These factors include environmental, especially infectious factors, translocations, mutations and genetic instability. The special microenvironment in the skin is responsible for the peculiar behavior of these neoplasms by providing various key factors, such as adhesion molecules and cytokines. Newly identified molecular disturbances in cutaneous lymphomas might be fargeted by specific molecular or immunologic interventions in the future.

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