Immunosuppressive and Cytotoxic Drugs in the Treatment of Rheumatic Skin Disorders

RHEUMATIC DISEASES AND THE SKIN

Immunosuppressive and Cytotoxic Drugs in the Treatment of Rheumatic Skin Disorders

Mar
2001
Vol. 20. No. 1
Jeffrey P Callen, MD

Cytotoxic and Immunosuppressive drugs are regularly used to treat proliferative, immunologically mediated inflammatory disorders and some neoplastic diseases of the skin. Methotrexate, azathioprine, mycophenolate mofefil, cyclosporin cyclophosphamide, chlorambucil, and other related drugs have potential benefits in the treatment of severe and/or recalcitrant rheumatic skin diseases. The therapeutic window for these agents is narrow. The major uses of these drugs are for life threatening cutaneous disorders or as steroidsparing agents.

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