Cutaneous T-Cell Lymphomas: A Review With Emphasis on New Treatment Approaches

CURRENT THERAPIES

Cutaneous T-Cell Lymphomas: A Review With Emphasis on New Treatment Approaches

Sep
2003
Vol. 22. No. 3
Joan Guitart, MD | Christiane Querfeld, MD | Steven T Rosen, MD | Timothy M Kuzel, MD

Primary cutaneous T-cell lymphomas represent a wide variety of non-Hodgkin lymphomas that are characterized by a distinct clinical presentation. Advanced molecular and biological techniques have enhanced the recognition of cutaneous Tcell lymphomas. The most common subtypes of cutaneous T-cell lymphomas are the epidermotropic variants mycosis fungoides and Se┬┤zary syndrome. At present, a stage-adjusted therapy is the best concept available, since early aggressive treatment options did not improve the prognosis of patients with cutaneous T-cell lymphomas. Accurate diagnostic and clinical assessment as well as identification of prognostic factors provides a helpful basis for treatment strategies. Current medical literature on diagnosis, prognosis, and treatment is reviewed with emphasis on new biologic response-modifying treatment options.

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