Acne, Introduction

ACNE

Acne, Introduction

Sep
2001
Vol. 20. No. 3
Diane Thiboutot, MD

IN THIS ISSUE of Seminars in Cutaneous Medicine and Surgery, we present an overview of some of the current issues in the pathophysiology and therapy of acne and rosacea. Updates are provided on the evolving role of Propionibacterium acnes in acne including issues regarding the development of antibiotic resistance and the role of this bacterium in the inflammation associated with acne. Hormonal aspects of acne are of particular interest in treating adult women. A review of the role of hormones in acne, guidelines for the work-up of a suspected endocrine disorder, and an overview of the use of hormonal therapy in women with endocrine problems and in normal women are presented. Recently, advances in the treatment of acne have been made with the development of novel retinoids such as tazarotene and agents with retinoid activity such as adapalene. Background information and guidelines for the use of topical retinoids in the management of acne are presented. Isotretinoin is a mainstay in the treatment of severe ache. It is the only agent that affects each of the pathogenic features of this disease.

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