PRECISION MEDICINE
Strategies to maximize treatment success in moderate to severe psoriasis: establishing treatment goals and tailoring of biologic therapies
Jun
2014
Vol. 33. No. 2
Achieving treatment success among patients with
moderate to severe psoriasis is a clinically relevant and
important issue facing clinicians and patients. Despite
advances in systemic therapy, most patients with moderate
to severe psoriasis are not satisfied with their treatment.
We will discuss strategies to maximize treatment
success through the establishment of treatment goals
and tailoring of biologic therapy for patients with difficultto-
treat psoriasis. Specifically, we provide evidence-based
highlights on the development of biologics, recommendations
by psoriasis expert groups on treatment goals,
approaches to achieve treatment to defined targets, and
therapeutic strategies to customize biologic treatment for
nonresponders. The discussion on nonresponders focuses
on subpopulations of interest including patients with
significant obesity, antidrug antibody formation, personal
preferences for medication administration, and treatment
nonadherence. We also highlight circumstances where
the selection of the systemic medication is driven by safety
considerations. As expectation for efficacy and safety increases
with continued biologic development for psoriasis,
devising real-world treatment strategies to maximize treatment
success is critical to improve the overall physical and
psychosocial wellbeing of psoriasis patients.
Semin Cutan Med Surg 33:91-97 © 2014 Frontline Medical
Communications
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