PRECISION MEDICINE
Merkel cell carcinoma: current status of targeted and future potential for immunotherapies
Jun
2014
Vol. 33. No. 2
Merkel cell carcinoma is an aggressive neuroendocrine
tumor with a high incidence of local recurrence, regional
nodal and distant metastasis, and a high mortality rate. It
has been linked to a polyomavirus in addition to immune
suppression. Traditionally, treatment options have been limited
to surgery and radiation therapy. Better understanding
of the molecular pathways of infection and carcinogenesis
has provided potential molecular targets and potential
immunotherapies which are discussed in this review.
Semin Cutan Med Surg 33:76-82 © 2014 Frontline Medical
Communications
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