Fractional epidermal grafting in combination with laser therapy as a novel approach in treating radiation dermatitis

ADVANCES IN LASER SCAR REHABILITATION

Fractional epidermal grafting in combination with laser therapy as a novel approach in treating radiation dermatitis

Mar
2015
Vol. 34. No. 1
Andrew Ziegler | Martin Purschke, PhD | Minh Van Hoang, MD | Quynh-Anh Ngoc Phan, MD | R Rox Anderson, MD | Sameer Sabir | Stuart Nelson, MD, PhD | Thanh-Nga Trinh Tran, MD, PhD | Thuy L Phung, MD, PhD | William A Farinelli
Radiation injury to the skin is a major source of dysfunction, disfigurement, and complications for thousands of patients undergoing adjunctive treatment for internal cancers. Despite the great potential for affecting quality of life, radiation injury has received little attention from dermatologists and is primarily being managed by radiation oncologists. During our volunteer work in Vietnam, we encountered numerous children with significant scarring and depigmentation of skin from the outdated use of radioactive phosphorus P32 in the treatment of hemangiomas. This dangerous practice has left thousands of children with significant fibrosis and disfigurement. Currently, there is no treatment for radiation dermatitis. Here, we report a case series using the combination of laser treatment, including pulsed-dye laser, fractional CO2 laser, and epidermal grafting to improve the appearance and function of the radiation scars in these young patients. We hope that by improving the appearance and function of these scars, we can improve the quality of life for these young patients and potentially open up a new avenue of treatment for cancer patients affected with chronic radiation dermatitis, potentially improving their range of motion, cosmesis, and reducing their risk of secondary skin malignancies. Semin Cutan Med Surg 34:42-47 © 2015 Frontline Medical Communications
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