Pigmentary abnormalities are among the most common reasons why patients with skin of
color visit a dermatologist. Hydroquinone has been a cornerstone for the treatment of
hyperpigmentation; however, concerns regarding adverse effects have prompted a search
for alternative agents. Some promising topical treatments include soy, licorice, rucinol,
mulberry, niacinamide, ellagic acid, resveratrol, and dioic acid. Oral agents, primarily used
for the prevention of postprocedural hyperpigmentation, include procyanidins, tranexamic
acid, and Polypodium leucotomos. Advances in Q-switched lasers, intense pulse light,
fractional photothermolysis, and the advent of tretinoin peeling add to the clinician’s
armamentarium for treating hyperpigmentation.
Semin Cutan Med Surg 31:133-139 © 2012 Elsevier Inc. All rights reserved.